PDRN was first deployed as a tissue repairing compound in Italy after approval in 2008 due to its special ability to accelerate recovery after skin grafts. HP Nucleo Vital combines 2000 ppm of PDRN and 5000 ppm of Hyaluric Acid, has taken over the role of PDRN products. Combine one Glamour Hyaluronic Acid skinboosters syringe with one bottle of HP Nucleo Vital to reach the best result you want.